QUATERNARY-SALTS OF 2-[(HYDROXYIMINO)METHYL]IMIDAZOLE .3. SYNTHESIS AND EVALUATION OF (ALKENYLOXY)METHYL, (ALKYNYLOXY)METHYL, AND (ARALKYLOXY)METHYL QUATERNARIZED 2-[(HYDROXYIMINO)METHYL]-1-ALKYLIMIDAZOLIUM HALIDES AS REACTIVATORS AND THERAPY FOR SOMAN INTOXICATIONO

被引:32
作者
BEDFORD, CD
HARRIS, RN
HOWD, RA
GOFF, DA
KOOLPE, GA
PETESCH, M
KOPLOVITZ, I
SULTAN, WE
MUSALLAM, HA
机构
[1] SRI INT,DEPT ORGAN CHEM,MENLO PK,CA 94025
[2] SRI INT,BIOMED RES LAB,MENLO PK,CA 94025
[3] USA,MED RES INST CHEM DEF,DRUG TESTING & EVALUAT BRANCH,ABERDEEN PROVING GROUND,MD 21010
[4] WALTER REED ARMY INST RES,DEPT MED CHEM,WASHINGTON,DC 20307
关键词
D O I
10.1021/jm00122a035
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:504 / 516
页数:13
相关论文
共 33 条
[1]  
ALBERT A, 1968, IONIZATION CONSTANTS, P49
[2]  
ASHANI Y, 1965, ISR J CHEM, V3, P133
[3]  
BAKER EL, 1978, LANCET, V1, P31
[4]   QUATERNARY-SALTS OF 2-[(HYDROXYIMINO)METHYL]IMIDAZOLE .2. PREPARATION AND INVITRO AND INVIVO EVALUATION OF 1-(ALKOXYMETHYL)-2-[(HYDROXYIMINO)METHYL]-3-METHYLIMIDAZOLIUM HALIDES FOR REACTIVATION OF ORGANOPHOSPHORUS-INHIBITED ACETYLCHOLINESTERASES [J].
BEDFORD, CD ;
HARRIS, RN ;
HOWD, RA ;
GOFF, DA ;
KOOLPE, GA ;
PETESCH, M ;
MILLER, A ;
NOLEN, HW ;
MUSALLAM, HA ;
PICK, RO ;
JONES, DE ;
KOPLOVITZ, I ;
SULTAN, WE .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (02) :493-503
[5]   NONQUATERNARY CHOLINESTERASE REACTIVATORS .3. 3(5)-SUBSTITUTED 1,2,4-OXADIAZOL-5(3)-ALDOXIMES AND 1,2,4-OXADIAZOLE-5(3)-THIOCARBOHYDROXIMATES AS REACTIVATORS OF ORGANOPHOSPHONATE-INHIBITED EEL AND HUMAN ACETYLCHOLINESTERASE INVITRO [J].
BEDFORD, CD ;
HOWD, RA ;
DAILEY, OD ;
MILLER, A ;
NOLEN, HW ;
KENLEY, RA ;
KERN, JR ;
WINTERLE, JS .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (11) :2174-2183
[6]   NONQUATERNARY CHOLINESTERASE REACTIVATORS .4. DIALKYLAMINOALKYL THIOESTERS OF ALPHA-KETO THIOHYDROXIMIC ACIDS AS REACTIVATORS OF ETHYL METHYLPHOSPHONYL AND 1,2,2-TRIMETHYLPROPYL METHYLPHOSPHONYL-ACETYLCHOLINESTERASE INVITRO [J].
BEDFORD, CD ;
MIURA, M ;
BOTTARO, JC ;
HOWD, RA ;
NOLEN, HW .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (09) :1689-1696
[7]   STRUCTURE ACTIVITY RELATIONSHIPS FOR REACTIVATORS OF ORGANOPHOSPHORUS-INHIBITED ACETYLCHOLINESTERASE - QUATERNARY-SALTS OF 2-[(HYDROXYIMINO)METHYL]IMIDAZOLE [J].
BEDFORD, CD ;
HARRIS, RN ;
HOWD, RA ;
MILLER, A ;
NOLEN, HW ;
KENLEY, RA .
JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (11) :1431-1438
[8]   AN EASILY INTRODUCED AND REMOVED PROTECTING GROUP FOR IMIDAZOLE NITROGEN - A CONVENIENT ROUTE TO 2-SUBSTITUTED IMIDAZOLES [J].
CURTIS, NJ ;
BROWN, RS .
JOURNAL OF ORGANIC CHEMISTRY, 1980, 45 (20) :4038-4040
[9]   OXIMES ANTAGONISTIC TO INHIBITORS OF CHOLINESTERASE .1. [J].
ELLIN, RI ;
WILLS, JH .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (09) :995-&
[10]  
ENGLEHARD N, 1967, ANGEW CHEM INT EDIT, V6, P615