ANALYSES OF CRYOGENIC SAMPLES USING ION-INDUCED DESORPTION AND MULTIPHOTON RESONANCE IONIZATION

被引:10
作者
ERVIN, MH [1 ]
WOOD, MC [1 ]
WINOGRAD, N [1 ]
机构
[1] PENN STATE UNIV,DEPT CHEM,152 DAVEY LAB,UNIV PK,PA 16802
关键词
D O I
10.1021/ac00052a018
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
In this study, ion-beam-induced desorption with multiphoton resonance ionization detection of desorbed neutral molecules is used to characterize frozen aqueous solutions. This type of matrix is of particular importance since it serves as a model for biological matrices. The time-of-flight mass spectrum, obtained in this way for a millimolar tryptophan/H2O solution, is virtually identical to that for a submonolayer tryptophan on a silicon wafer. The tryptophan signal from a frozen solution is demonstrated to have a linear dependence on concentration by using 4,4'4-biphenyldiol as an internal standard. A detection limit of 2 X 10(-6) M Is also demonstrated. Since our ion beam samples one layer of 0. 1 cm2 and we assume 10(15) molecules/cm2 of ice, this concentration corresponds to approximately 4 X 10(6) molecules/layer. It is also shown that the signal exhibits an exponential decay with primary ion dose due to the accumulation of primary ion damage in the near-surface molecules.
引用
收藏
页码:417 / 420
页数:4
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