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DIFFERENTIAL-EFFECTS OF OMEGA-CONOTOXIN GVIA AND MVIIC ON NERVE-STIMULATION INDUCED CONTRACTIONS OF GUINEA-PIG ILEUM AND RAT VAS-DEFERENS

被引：30
作者：
BOOT, JR
机构：
[1] Eli Lilly and Co., Lilly Research Centre Ltd., Windlesham
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 258卷 / 1-2期
关键词：
OMEGA-CONOTOXIN MVIIC; OMEGA-CONOTOXIN GVIA; N-TYPE VOLTAGE-DEPENDENT CA2+ CHANNEL; ILEUM; GUINEA PIG; VAS DEFERENS; RAT;
D O I：
10.1016/0014-2999(94)90069-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
omega-Conotoxin GVIA and omega-conotoxin MVIIC caused similar concentration-dependent reductions of the electrically induced twitch responses of guinea-pig ileum. The inhibitory effects of omega-conotoxin GVIA were long-lasting whereas those to omega-conotoxin MVIIC were readily reversed. Preincubation with omega-conotoxin MVIIC prevented the irreversible inhibition of omega-conotoxin GVIA suggesting a common site of interaction. However, unlike omega-conotoxin GVIA which caused inhibition, omega-conotoxin MVIIC did not affect the electrically induced twitch responses of the rat vas deferens nor did it prevent the irreversible inhibition with omega-conotoxin GVIA. This study indicates the possible existence of different subtypes of the N-type voltage-dependent calcium channel.
引用
收藏
页码：155 / 158
页数：4
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