SEROTONERGIC PATHOLOGY IS NOT WIDESPREAD IN ALZHEIMER PATIENTS WITHOUT PROMINENT AGGRESSIVE SYMPTOMS

被引：70

作者：

PROCTER, AW ^{[1
]}

FRANCIS, PT ^{[1
]}

STRATMANN, GC ^{[1
]}

BOWEN, DM ^{[1
]}

机构：

[1] UNIV MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT PSYCHIAT,LONDON SE1 9RT,ENGLAND

来源：

NEUROCHEMICAL RESEARCH | 1992年 / 17卷 / 09期

关键词：

ALZHEIMERS DISEASE; BEHAVIOR; SEROTONIN; CEREBRAL CORTEX;

D O I：

10.1007/BF00993268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Behavioural symptoms of Alzheimer's disease, such as aggression, may determine the care patients required. Most postmortem neurochemical studies have been of institutionalized patients and conclusions drawn from these may not be valid for all patients. We have shown that serotonin 2 receptors are not lost from 12 of the 13 areas of cerebral cortex examined in the patients assessed to be free of aggressive symptoms. This has been interpreted as representing the relative preservation of cortical interneurones. In contrast choline acetyltransferase activity was reduced in all areas whereas serotonin content was reduced in only 2 of the 4 areas examined.

引用

页码：917 / 922

页数：6

共 35 条

[1] PSYCHIATRIC DIFFERENTIATION OF SENILITY AND ARTERIOSCLEROSIS [J].

BIRKETT, DP .

BRITISH JOURNAL OF PSYCHIATRY, 1972, 120 (556) :321-&

[2] CIRCUMSCRIBED CHANGES OF THE CEREBRAL-CORTEX IN NEUROPSYCHIATRIC DISORDERS OF LATER LIFE [J].

BOWEN, DM ;

NAJLERAHIM, A ;

PROCTER, AW ;

FRANCIS, PT ;

MURPHY, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9504-9508

[3]

BOWEN DM, 1991, IN PRESS J NEUROL NE

[4] PSYCHIATRIC PHENOMENA IN ALZHEIMERS-DISEASE .3. DISORDERS OF MOOD [J].

BURNS, A ;

JACOBY, R ;

LEVY, R .

BRITISH JOURNAL OF PSYCHIATRY, 1990, 157 :81-86

[5] PSYCHIATRIC PHENOMENA IN ALZHEIMERS-DISEASE .4. DISORDERS OF BEHAVIOR [J].

BURNS, A ;

JACOBY, R ;

LEVY, R .

BRITISH JOURNAL OF PSYCHIATRY, 1990, 157 :86-94

[6] DEMENTIA - THE EXPERIENCE OF FAMILY CAREGIVERS [J].

CHENOWETH, B ;

SPENCER, B .

GERONTOLOGIST, 1986, 26 (03) :267-272

[7] SEROTONIN RECEPTOR CHANGES IN DEMENTIA OF THE ALZHEIMER TYPE [J].

CROSS, AJ ;

CROW, TJ ;

FERRIER, IN ;

JOHNSON, JA ;

BLOOM, SR ;

CORSELLIS, JAN .

JOURNAL OF NEUROCHEMISTRY, 1984, 43 (06) :1574-1581

[8] 5HT2 RECEPTORS IN DEMENTIA OF THE ALZHEIMER TYPE - A QUANTITATIVE AUTORADIOGRAPHIC STUDY OF FRONTAL-CORTEX AND HIPPOCAMPUS [J].

DEWAR, D ;

GRAHAM, DI ;

MCCULLOCH, J .

JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION, 1990, 2 (02) :129-137

[9]

DRESSE A, 1988, CLIN NEUROPHARMAC S2, V11, P551

[10]

FRANCIS PT, 1991, IN PRESS J PHARM EXP

← 1 2 3 4 →