HEMOGLOBIN-BASED RED-CELL SUBSTITUTES - CURRENT STATUS

被引：18

作者：

OGDEN, JE ^{[1
]}

MACDONALD, SL ^{[1
]}

机构：

[1] SCOTTISH NATL BLOOD TRANSFUS SERV, NATL SCI LAB, EDINBURGH, MIDLOTHIAN, SCOTLAND

来源：

VOX SANGUINIS | 1995年 / 69卷 / 04期

关键词：

D O I：

10.1111/j.1423-0410.1995.tb00365.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chemically modified haemoglobin solutions represent a potential alternative to the transfusion of donor blood. The theoretical advantages of these products include an oxygen delivery potential greater than that of conventional plasma expanders, prolonged shelf-life, universal compatibility and the absence of pathogenic viruses. Principal concerns have been safety issues including renal toxicity, coagulopathy and vasoactivity, The proposed indications for these solutions are primarily resuscitation of patients in haemorrhagic shock and porioperative haemodilution during elective surgery. Three products have now undergone phase I safety trials in human subjects and phase II safety and efficacy trials are planned in the near future.

引用

页码：302 / 308

页数：7

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