FETAL HOMOTRANSPLANTS (VENTRAL MESENCEPHALON AND ADRENAL-TISSUE) TO THE STRIATUM OF PARKINSONIAN SUBJECTS

被引:85
作者
MADRAZO, I
FRANCOBOURLAND, R
OSTROSKYSOLIS, F
AGUILERA, M
CUEVAS, C
ZAMORANO, C
MORELOS, A
MAGALLON, E
GUIZARSAHAGUN, G
机构
[1] INST MEXICANO SEGURO SOCIAL, CTR MED SIGLO 21, DEPT CLIN RES NEUROL & NEUROSURG, MEXICO CITY 7, DF, MEXICO
[2] INST NACL NUTR SALVADOR ZUBIRAN, DEPT BIOCHEM, MEXICO CITY 14000, DF, MEXICO
[3] NATL AUTONOMOUS UNIV MEXICO, FAC PSICOL, DEPT PSYCHOPHYSIOL, MEXICO CITY 04510, DF, MEXICO
关键词
D O I
10.1001/archneur.1990.00530120025005
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Fetal ventral mesencephalon and fetal adrenal tissue grafted to the caudate nucleus of four and three parkinsonian patients, respectively, have been shown to be an alternative treatment for the amelioration of the signs of the disease. The ventral mesencephalon patients had a significant amelioration of rigidity, bradykinesia, postural imbalance, gait disturbance, and facial expression. Three of these four patients have returned to work. The fatal adrenal group only showed amelioration of rigidity and bradykinesia. Though these patients are now able to perform their basic daily living activities, and one of them has renewed her household tasks, the other two have not yet been able to return to work. The differences observed between the ventral mesencephalon- and the fetal adrenal-transplanted patients may be related to the heterogeneity of their disease and/or the type of graft implanted. However encouraging our results may be, this experimental procedure obviously requires further studies, and should not be practiced outside of highly qualified clinical research centers. © 1990, American Medical Association. All rights reserved.
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页码:1281 / 1285
页数:5
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