ACETYLCHOLINESTERASE-STAINED SUCTION RECTAL BIOPSIES IN THE DIAGNOSIS OF HIRSCHSPRUNGS-DISEASE

被引：28

作者：

SCHOFIELD, DE ^{[1
]}

DEVINE, W ^{[1
]}

YUNIS, EJ ^{[1
]}

机构：

[1] CHILDRENS HOSP,DEPT PATHOL,PITTSBURGH,PA 15213

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 1990年 / 11卷 / 02期

关键词：

Acetylcholinesterase stain; Hirschsprung’s disease; Intestinal aganglionosis;

D O I：

10.1097/00005176-199008000-00012

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Conflicting reports in the literature regarding the sensitivity and specificity of the acetylcholinesterase (AChE) stain in establishing or excluding the diagnosis of Hirschsprung’s disease (HD) prompted this review of 497 rectal biopsies performed on 455 children. Using hematoxylin and eosin (H&E) to stain formalin-fixed, paraffin-embedded tissue sections is our preferred method of identifying ganglion cells. In this series, however, there were eight children with HD, and nine without HD in whom the AChE-stained portion of the sample provided invaluable diagnostic information not obtained from the concomitant, formalin-fixed, H&E-stained portion of the sample. The AChE stain also provided at least suggestive evidence of HD in some of the anal or anorectal biopsy specimens. © 1990 Raven Press Ltd, New York.

引用

页码：221 / 228

页数：8

共 25 条

[21] THE VALIDITY OF RECTAL BIOPSY IN RELATION TO MORPHOLOGY AND DISTRIBUTION OF GANGLION-CELLS [J].