EFFECT OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS ON FRACTURE-HEALING - A LABORATORY STUDY IN RATS

被引:176
作者
ALTMAN, RD
LATTA, LL
KEER, R
RENFREE, K
HORNICEK, FJ
BANOVAC, K
机构
[1] UNIV MIAMI,VET ADM HOSP,SCH MED,DEPT MED,MIAMI,FL 33101
[2] UNIV MIAMI,VET ADM HOSP,SCH MED,DEPT ORTHOPAED & REHABIL,MIAMI,FL 33101
关键词
IBUPROFEN; INDOMETHACIN; FRACTURE HEALING; RATS;
D O I
10.1097/00005131-199505000-00006
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
We studied the effects of two nonsteroidal antiinflammatory drugs (NSAIDs) on fracture healing in rats: ibuprofen (30 mg/kg/day) and indomethacin (1 mg/kg/day). Femoral fractures were induced via a three-point bending technique. NSAIDs were administered orally for 4 or 12 weeks. Control animals received no medication. In each group a minimum of six animals were killed at the following intervals: 2, 4, 6, 8, 10, and 12 weeks postfracture. Fracture healing was determined by mechanical testing and histologic evaluation. The bending strength of each fractured femur was expressed as a percentage of the strength of the intact, contralateral femur. Histologic evaluation was performed on serial longitudinal sections stained with hematoxylin and eosin using a qualitative score of maturity of the callus. Ibuprofen and indomethacin both retarded fracture healing, with significant differences in ''mechanical healing'' found between the control and experimental groups after 10 weeks of drug administration. Both drugs also induced qualitative histologic changes manifested by delayed maturation of callus, which was noticeable earlier than the difference found by mechanical testing of bane. Our data suggest that NSAIDs have an inhibitory effect on fracture repair that is reversible after cessation of indomethacin but not ibuprofen.
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页码:392 / 400
页数:9
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