NEW STRATEGIES FOR ENHANCING THE IMMUNOGENICITY OF TUMORS

被引：90

作者：

PARDOLL, DM

机构：

[1] The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, 720 Rutland Avenue

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 05期

关键词：

D O I：

10.1016/0952-7915(93)90127-E

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

When a cancer grows in an individual, the immune system has either failed to recognize its antigens or failed to effectively respond. Increasing evidence for the existence of tumor antigens that are recognized by T cells provides a direct rationale for the design of novel strategies to either enhance tumor immunogenicity by genetic modification or utilize recombinant or peptide vaccines in cases where the relevant tumor antigens have been specifically identified.

引用

页码：719 / 725

页数：7

共 33 条

[31] A GENE ENCODING AN ANTIGEN RECOGNIZED BY CYTOLYTIC LYMPHOCYTES-T ON A HUMAN-MELANOMA [J].