EFFECT OF PROTEIN-KINASE-C INHIBITORS ON THE ANTIVIRAL ACTIVITY OF HUMAN ALPHA-INTERFERON IN HERPES-SIMPLEX VIRUS-INFECTED HUMAN NEUROBLASTOMA-CELLS

被引:4
作者
CHATTERJEE, S [1 ]
BURNS, P [1 ]
KOGA, J [1 ]
机构
[1] JCR PHARMACEUT,KOBE 65122,JAPAN
关键词
D O I
10.1128/JVI.69.2.1315-1318.1995
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Pretreatment of human neuroblastoma cells with an inhibitor of protein kinase C (PKC), staurosporine or H-7, prior to the addition of human alpha interferon (HuIFN-alpha), recombinant HuIFN-alpha, or recombinant HuIFN-beta blocked the inhibitory effect of these IFNs on the release of infectious herpes simplex virus type 1 from treated cells. In addition, staurosporine blocked the inhibitory effect of HuIFNs on the expressions of herpes simplex type 1 glycoproteins B, C, and D in treated neuroblastoma cells. Furthermore, addition of HuIFNs resulted in an increased expression of PKC in treated neuroblastoma cells. These results suggest that inhibitors of PKC block the expression of HuIFN-induced genes in treated human neuroblastoma cells. Thus, the activation of PKC is an important step in the HuIFN-treated cells of neuronal origin.
引用
收藏
页码:1315 / 1318
页数:4
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