NOVEL PACKAGES OF VIRAL AND SELF-ANTIGENS ARE GENERATED DURING APOPTOSIS

被引：198

作者：

ROSEN, A

CASCIOLAROSEN, L

AHEARN, J

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT DERMATOL, BALTIMORE, MD 21205 USA

[2] JOHNS HOPKINS UNIV, SCH MED, DEPT MOLEC BIOL & GENET, BALTIMORE, MD 21205 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1995年 / 181卷 / 04期

关键词：

D O I：

10.1084/jem.181.4.1557

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune context is an essential determinant of the host response to potential autoantigens. The clustering of the autoantigens targeted in systemic lupus erythematosus within surface blebs of apoptotic cells generates high concentrations of autoantigen within discrete subcellular packages. We demonstrate here that when apoptosis is induced by Sindbis virus infection, viral antigens and autoantigens cocluster exclusively in small surface blebs of apoptotic cells. The surface of these blebs is rich in viral glycoproteins, and virions can be seen blebbing from their surface. We propose that these blebs of mixed foreign and self-origin define a novel immune context that may challenge self-tolerance.

引用

页码：1557 / 1561

页数：5

共 18 条

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