SIMULATION OF PROTEIN-FOLDING PATHWAYS - LOST IN (CONFORMATIONAL) SPACE

Simulations of protein folding using simplified models can reproduce many of the qualitative features of natural protein-folding pathways. In many ways, simulations complement conventional experimental techniques for studying protein folding, as they can be used to probe processes that are otherwise inaccessible with current techniques, Manipulating simulation parameters can provide information on the origins of specific folding behaviors; however, some stages of the folding process remain difficult to model with available methods.