AMMONIA STIMULATES THE RELEASE OF TAURINE FROM CULTURED ASTROCYTES

被引：29

作者：

ALBRECHT, J

BENDER, AS

NORENBERG, MD

机构：

[1] UNIV MIAMI,SCH MED,DEPT PATHOL,NEUROPATHOL LAB,MIAMI,FL 33101

[2] VET ADM MED CTR,MIAMI,FL 33101

[3] POLISH ACAD SCI,MED RES CTR,DEPT NEUROPATHOL,PL-00784 WARSAW,POLAND

来源：

BRAIN RESEARCH | 1994年 / 660卷 / 02期

关键词：

AMINO ACID RELEASE; AMMONIUM CHLORIDE; ASTROCYTES; GABA; GLUTAMATE; HEPATIC ENCEPHALOPATHY; TAURINE;

D O I：

10.1016/0006-8993(94)91301-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of ammonia on the release of the neuroactive amino acids taurine (TAU), gamma-aminobutyric acid (GABA) and D-aspartate (D-ASP), an analog of L-glutamate (L-GLU), from cultured rat cortical astrocytes was studied. NH4Cl (1 and 5 mM) induced the release of TAU. TAU release was reduced when Na+ was removed, and was almost completely abolished when Cl- was omitted. In contrast, TAU basal release was enhanced upon removal of Na+ or Cl-. Ammonia inhibited the release of GABA and D-ASP. Ammonia-induced release of astroglial TAU may modify the neuronal excitability accompanying hyperammonemic conditions.

引用

收藏

页码：288 / 292

页数：5

相关论文

共 36 条

[11] EXPRESSION OF EXCITATORY AMINO-ACID RECEPTORS BY CEREBELLAR CELLS OF THE TYPE-2 ASTROCYTE CELL LINEAGE [J].

GALLO, V ;

GIOVANNINI, C ;

SUERGIU, R ;

LEVI, G .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (01) :1-9

[12] AMMONIA-INDUCED SWELLING OF RAT CEREBRAL CORTICAL SLICES - IMPLICATIONS FOR THE PATHOGENESIS OF BRAIN EDEMA IN ACUTE HEPATIC-FAILURE [J].

GANZ, R ;

SWAIN, M ;

TRABER, P ;

DALCANTO, M ;

BUTTERWORTH, RF ;

BLEI, AT .

METABOLIC BRAIN DISEASE, 1989, 4 (03) :213-223

[13] RELEASE OF ASPARTATE AND GLUTAMATE CAUSED BY CHLORIDE REDUCTION IN SYNAPTOSOMAL INCUBATION MEDIA [J].

HARDY, JA ;

BOAKES, RJ ;

THOMAS, DJE ;

KIDD, AM ;

EDWARDSON, JA ;

VIRMANI, M ;

TURNER, J ;

DODD, PR .

JOURNAL OF NEUROCHEMISTRY, 1984, 42 (03) :875-877

[14] EFFECT OF ACUTE AMMONIA INTOXICATION ON CEREBRAL METABOLISM IN RATS WITH PORTACAVAL SHUNTS [J].

HINDFELT, B ;

PLUM, F ;

DUFFY, TE .

JOURNAL OF CLINICAL INVESTIGATION, 1977, 59 (03) :386-396

[15] TAURINE AND BETA-ALANINE UPTAKE IN PRIMARY ASTROCYTES DIFFERENTIATING IN CULTURE - EFFECTS OF IONS [J].

HOLOPAINEN, I .

NEUROCHEMICAL RESEARCH, 1988, 13 (09) :853-858

[16]

KIMELBERG HK, 1990, J NEUROSCI, V10, P1583

[17] CHARACTERISTICS OF TAURINE RELEASE FROM CEREBRAL-CORTEX SLICES INDUCED BY SODIUM-DEFICIENT MEDIA [J].

KORPI, ER ;

OJA, SS .

BRAIN RESEARCH, 1983, 289 (1-2) :197-204

[18] AMINO-ACID CHANGES IN AUTOPSIED BRAIN-TISSUE FROM CIRRHOTIC-PATIENTS WITH HEPATIC-ENCEPHALOPATHY [J].

LAVOIE, J ;

GIGUERE, JF ;

LAYRARGUES, GP ;

BUTTERWORTH, RF .

JOURNAL OF NEUROCHEMISTRY, 1987, 49 (03) :692-697

[19] BETA-ADRENERGIC-AGONIST STIMULATED TAURINE RELEASE FROM ASTROGLIAL CELLS IS MODULATED BY EXTRACELLULAR [K+] AND OSMOLARITY [J].

MARTIN, DL ;

SHAIN, W .

NEUROCHEMICAL RESEARCH, 1993, 18 (04) :437-444

[20] THE RELEASE AND NEOSYNTHESIS OF GLUTAMIC-ACID ARE INCREASED IN EXPERIMENTAL-MODELS OF HEPATIC-ENCEPHALOPATHY [J].

MORONI, F ;

LOMBARDI, G ;

MONETI, G ;

CORTESINI, C .

JOURNAL OF NEUROCHEMISTRY, 1983, 40 (03) :850-854

← 1 2 3 4 →