21-AMINOSTEROIDS ATTENUATE EXCITOTOXIC NEURONAL INJURY IN CORTICAL CELL-CULTURES

被引：203

作者：

MONYER, H ^{[1
]}

HARTLEY, DM ^{[1
]}

CHOI, DW ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,DEPT NEUROL,STANFORD,CA 94305

来源：

NEURON | 1990年 / 5卷 / 02期

关键词：

D O I：

10.1016/0896-6273(90)90302-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the protective efficacy of novel 21-aminosteroids against several forms of neuronal injury in murine cortical cell cultures. Concentrations of 200 nM to 20 μM partially attenuated the damage induced by glucose deprivation, combined oxygen-glucose deprivation, or exposure to NMDA; maximal protection was less than that produced by NMDA antagonists, but the combination of a 21-aminosteroid plus an NMDA antagonist produced a greater benefit than either drug alone. 21-Aminosteroid addition did not attenuate NMDA-induced whole-cell current, but did block almost all of the damage induced by exposure to iron, a protective action consistent with inhibition of free radical-mediated lipid peroxidation. Lipid peroxidation may be a downstream event mediating a portion of the injury triggered by excess stimulation of NMDA receptors. © 1990.

引用

页码：121 / 126

页数：6

共 37 条

[31] BLOCKADE OF N-METHYL-D-ASPARTATE RECEPTORS MAY PROTECT AGAINST ISCHEMIC DAMAGE IN THE BRAIN [J].