ANGIOTENSIN-I CONVERTING-ENZYME GENE - REGULATION, POLYMORPHISM AND IMPLICATIONS IN CARDIOVASCULAR-DISEASES

被引：28

作者：

SOUBRIER, F ^{[1
]}

NADAUD, S ^{[1
]}

WILLIAMS, TA ^{[1
]}

机构：

[1] INSERM,U36,F-75005 PARIS,FRANCE

来源：

EUROPEAN HEART JOURNAL | 1994年 / 15卷

关键词：

INSERTION/DELETION POLYMORPHISM; MAJOR GENE; MYOCARDIAL INFARCTION; LEFT VENTRICULAR HYPERTROPHY;

D O I：

10.1093/eurheartj/15.suppl_D.24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Angiotensin I converting enzyme (ACE), also called dipeptidyl-carboxypeptidase I (DCPI), is a zinc metallopeptidase widely distributed on the surface of endothelial and epithelial cells. Its role in the vasoactive peptide, the metabolism of the two active peptides, angiotensin and bradykinin, and the beneficial effects of its inhibition in cardiovascular diseases, have raised considerable interest in this enzyme. The potential implications of ACE gene polymorphism, which affects the expression of the gene in cardiovascular diseases, has been widely investigated. This review summarizes the results of these studies

引用

页码：24 / 29

页数：6

共 63 条

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