A REACTION CALORIMETRIC INVESTIGATION OF THE HYDROGENATION OF A SUBSTITUTED PYRAZINE

被引：27

作者：

LANDAU, RN ^{[1
]}

SINGH, U ^{[1
]}

GORTSEMA, F ^{[1
]}

SUN, YK ^{[1
]}

GOMOLKA, SC ^{[1
]}

LAM, T ^{[1
]}

FUTRAN, M ^{[1
]}

BLACKMOND, DG ^{[1
]}

机构：

[1] MERCK & CO INC,RAHWAY,NJ 07065

来源：

JOURNAL OF CATALYSIS | 1995年 / 157卷 / 01期

关键词：

D O I：

10.1006/jcat.1995.1280

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Reaction calorimetry was the primary tool in investigations of the liquid-phase hydrogenation of a substituted pyrazine compound carried out over supported Pd catalysts. In addition to providing information about gas-liquid mass transfer limitations, calorimetric measurements provided a kinetic analysis of how product selectivity in this consecutive reaction network may be tuned by changing reaction conditions. Concentration profiles developed from fitting the heat flow data to a first-order model were compared with analytical measurements of concentration, demonstrating the utility of combining independent measurements of reaction progress as a means of assessing the validity of a kinetic model. (C) 1995 Academic Press, Inc.

引用

页码：201 / 208

页数：8

共 16 条

[1] HIGHLY DIASTEREOSELECTIVE REACTION OF A CHIRAL, NON-RACEMIC AMIDE ENOLATE WITH (S)-GLYCIDYL TOSYLATE - SYNTHESIS OF THE ORALLY-ACTIVE HIV-1 PROTEASE INHIBITOR L-735,524
ASKIN, D
ENG, KK
ROSSEN, K
PURICK, RM
WELLS, KM
VOLANTE, RP
REIDER, PJ
[J]. TETRAHEDRON LETTERS, 1994, 35 (05) : 673 - 676
[2] DALY FP, 1994, CATALYSIS ORGANIC RE, P13
[3] DEIMLING A, 1984, CHEM ENG J, V29, P140
[4] THE DEVELOPMENT AND USE OF QUANTUM-MECHANICAL MOLECULAR-MODELS .76. AM1 - A NEW GENERAL-PURPOSE QUANTUM-MECHANICAL MOLECULAR-MODEL
DEWAR, MJS
ZOEBISCH, EG
HEALY, EF
STEWART, JJP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (13) : 3902 - 3909
[5] GARLAND M, 1991, HETEROGENEOUS CATALY, V2, P177
[6] GUISNETMG, 1991, HETEROGENEOUS CATALY
[7] HAFELINGER VG, 1977, ANGEW CHEM, V89, P48
[8] CALORIMETRIC INVESTIGATION OF AN EXOTHERMIC REACTION - KINETIC AND HEAT-FLOW MODELING
LANDAU, RN
BLACKMOND, DG
TUNG, HH
[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1994, 33 (04) : 814 - 820
[9] LANDAU RN, 1994, CHEM ENG PROG NOV, P43
[10] MATSUMURA M, 1979, J FERMENT TECHNOL, V57, P107

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