2-SUBSTITUTED 2-AMINOETHANOL - MINIMUM ESSENTIAL STRUCTURE FOR IMMUNOSUPPRESSIVE ACTIVITY OF ISP-I (MYRIOCIN)

被引：24

作者：

FUJITA, T

HIROSE, R

HAMAMICHI, N

KITAO, Y

SASAKI, S

YONETA, M

CHIBA, K

机构：

[1] TAITO CO LTD,RES LAB,NAGATA KU,KOBE,HYOGO 653,JAPAN

[2] KYOTO UNIV,FAC PHARMACEUT SCI,SAKYO KU,KYOTO 60601,JAPAN

[3] YOSHITOMI PHARMACEUT IND LTD,RES LABS,IRUMA,SAITAMA 358,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 16期

关键词：

D O I：

10.1016/0960-894X(95)00304-C

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Substituted 2-aminoethanol was shown to be the minimum essential structure for the immunosuppressive activity of ISP-I (myriocin, thermozymocidin) by simplification of 2-substituted 2-amino-1,3-propanediol, which was generated by modification of ISP-I. Among the series, 2-amino-4-(4-octylphenyl)butanol hydrochloride displayed comparably potent activity to 2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride, FTY720.

引用

页码：1857 / 1860

页数：4

共 16 条

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