TRANSLOCATION (8,17)(P21,Q21), A POSSIBLE VARIANT OF T(15,17), IN ACUTE PROMYELOCYTIC LEUKEMIA

被引：19

作者：

MIURA, I ^{[1
]}

NISHINARI, T ^{[1
]}

HASHIMOTO, K ^{[1
]}

NIMURA, T ^{[1
]}

MIURA, S ^{[1
]}

MIURA, AB ^{[1
]}

机构：

[1] AKITA RED CROSS HOSP,DIV INTERNAL MED,AKITA,JAPAN

来源：

CANCER GENETICS AND CYTOGENETICS | 1994年 / 72卷 / 01期

关键词：

D O I：

10.1016/0165-4608(94)90115-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a 64-year old man with typical features of acute promyelocytic leukemia (APL) [M3, French-American-British (FAB) classification] in whom a variant, t(8;17)(q21;q21), was detected. This is the second case of the same variant translocation to be reported. The breakpoint on 17q was similar to those described in cases with a standard translocation 15;17. Consequently, this chromosome break or rearrangement at band 17q21, rather than the recipient site of translocation of the deleted material, appears to be of crucial importance in the genesis of APL.

引用

页码：75 / 77

页数：3

共 13 条

[1] PARTIAL DELETION OF LONG ARM OF CHROMOSOME-17 - SPECIFIC ABNORMALITY IN ACUTE PROMYELOCYTIC LEUKEMIA
GOLOMB, HM
ROWLEY, J
VARDIMAN, J
BARON, J
LOCKER, G
KRASNOW, S
[J]. ARCHIVES OF INTERNAL MEDICINE, 1976, 136 (07) : 825 - 828
[2] IS THE CHROMOSOMAL REGION 9Q34 ALWAYS INVOLVED IN VARIANTS OF THE PH1 TRANSLOCATION
HAGEMEIJER, A
BARTRAM, CR
SMIT, EME
VANAGTHOVEN, AJ
BOOTSMA, D
[J]. CANCER GENETICS AND CYTOGENETICS, 1984, 13 (01) : 1 - 16
[3] HARNDEN DG, 1985, CYTOGENET CELL GENET
[4] REPORT OF A VARIANT T(1-15-17)(P36-Q22-Q21.1) IN A PATIENT WITH ACUTE PROMYELOCYTIC LEUKEMIA
OSELLA, P
WYANDT, H
VOSBURGH, E
MILUNSKY, A
[J]. CANCER GENETICS AND CYTOGENETICS, 1991, 57 (02) : 201 - 207
[5] GENOMIC VARIABILITY AND ALTERNATIVE SPLICING GENERATE MULTIPLE PML/RAR-ALPHA TRANSCRIPTS THAT ENCODE ABERRANT PML PROTEINS AND PML/RAR-ALPHA ISOFORMS IN ACUTE PROMYELOCYTIC LEUKEMIA
PANDOLFI, PP
ALCALAY, M
FAGIOLI, M
ZANGRILLI, D
MENCARELLI, A
DIVERIO, D
BIONDI, A
LOCOCO, F
RAMBALDI, A
GRIGNANI, F
ROCHETTEEGLY, C
GAUBE, MP
CHAMBON, P
PELICCI, PG
[J]. EMBO JOURNAL, 1992, 11 (04) : 1397 - 1407
[6] ROWLEY JD, 1977, LANCET, V1, P549
[7] SANDBERG AA, 1990, CHROMOSOMES HUMAN CA
[8] ACUTE PROMYELOCYTIC LEUKEMIA - REPORT OF A VARIANT TRANSLOCATION, T(1-17)
SCHWARTZ, JG
CLARE, N
HANSEN, K
BRITTON, H
MANHOFF, L
[J]. CANCER GENETICS AND CYTOGENETICS, 1986, 20 (1-2) : 89 - 93
[9] SONODA Y, 1984, CANCER GENET CYTOGEN, V17, P61
[10] 2 CASES OF ACUTE PROMYELOCYTIC LEUKEMIA WITH VARIANT TRANSLOCATIONS - THE IMPORTANCE OF CHROMOSOME NO-17 ABNORMALITY
YAMADA, K
SUGIMOTO, E
AMANO, M
IMAMURA, Y
KUBOTA, T
MATSUMOTO, M
[J]. CANCER GENETICS AND CYTOGENETICS, 1983, 9 (02) : 93 - 99

← 1 2 →