ASYMMETRIC-SYNTHESIS OF OPTICALLY-ACTIVE DECAHYDROISOQUINOLINES USEFUL IN HIV-1 PROTEASE INHIBITOR SYNTHESIS

被引：8

作者：

TROVA, MP ^{[1
]}

MCGEE, KF ^{[1
]}

机构：

[1] AMER CYANAMID CO, DIV MED RES, ONCOL & IMMUNOL RES SECT, PEARL RIVER, NY 10965 USA

来源：

TETRAHEDRON | 1995年 / 51卷 / 21期

关键词：

D O I：

10.1016/0040-4020(95)00266-B

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of amino acid ester 8 is described featuring an asymmetric aza-Diels-Alder reaction of diene 5 and chiral imine 6 which establishes the asymmetry at C-3. Hydrogenation of 7 provides 8 with the desired asymmetry at C-4a and C-8a.

引用

页码：5951 / 5954

页数：4

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