Pregnancy and multiple sclerosis

被引:25
作者
Airas, Laura [1 ]
Kaaja, Risto [2 ,3 ]
机构
[1] Turku Univ Hosp, Dept Neurol, FI-20521 Turku, Finland
[2] Satakunta Cent Hosp, Pori, Finland
[3] Turku Univ, Turku, Finland
关键词
multiple sclerosis; pregnancy; immunosuppression;
D O I
10.1258/om.2012.110014
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The relapse rate of multiple sclerosis (MS) is typically reduced during late pregnancy but increases in the postpartum period. The reasons for the increased postpartum activity are not entirely clear, but factors such as the abrupt decrease in oestrogen levels immediately after the delivery and the loss of the immunosuppressive state of pregnancy are likely of importance. There is a general view that MS does not affect the course or outcome of pregnancy.
引用
收藏
页码:94 / 97
页数:4
相关论文
共 41 条
[21]   ACTIVITY OF MULTIPLE-SCLEROSIS DURING PREGNANCY AND PUERPERIUM [J].
KORNLUBETZKI, I ;
KAHANA, E ;
COOPER, G ;
ABRAMSKY, O .
ANNALS OF NEUROLOGY, 1984, 16 (02) :229-231
[22]   Exclusive Breastfeeding and the Risk of Postpartum Relapses in Women With Multiple Sclerosis [J].
Langer-Gould, Annette ;
Huang, Stella M. ;
Gupta, Rohit ;
Leimpeter, Amethyst D. ;
Greenwood, Eleni ;
Albers, Kathleen B. ;
Van den Eeden, Stephen K. ;
Nelson, Lorene M. .
ARCHIVES OF NEUROLOGY, 2009, 66 (08) :958-963
[23]   Estrogen receptor α mediates estrogen's immune protection in autoimmune disease [J].
Liu, HB ;
Loo, KK ;
Palaszynski, K ;
Ashouri, J ;
Lubahn, DB ;
Voskuhl, RR .
JOURNAL OF IMMUNOLOGY, 2003, 171 (12) :6936-6940
[24]   PREGNANCY AS A FACTOR INFLUENCING RELAPSE IN DISSEMINATED SCLEROSIS [J].
MILLAR, JHD ;
ALLISON, RS ;
CHEESEMAN, EA ;
MERRETT, JD .
BRAIN, 1959, 82 (03) :417-426
[25]   Birth outcomes and need for hospitalization after delivery among women with multiple sclerosis [J].
Mueller, BA ;
Zhang, JY ;
Critchlow, CW .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2002, 186 (03) :446-452
[26]   A review of the effects of breastfeeding on respiratory infections, atopy, and childhood asthma [J].
Oddy, WH .
JOURNAL OF ASTHMA, 2004, 41 (06) :605-621
[27]   Sex ratio of multiple sclerosis in Canada: a longitudinal study [J].
Orton, Sarah-Michelle ;
Herrera, Blanca M. ;
Yee, Irene M. ;
Valdar, William ;
Ramagopalan, Sreeram V. ;
Sadovnick, A. Dessa ;
Ebers, George C. .
LANCET NEUROLOGY, 2006, 5 (11) :932-936
[28]   Magnetic resonance imaging of the brain used to detect early post-parturn activation of multiple sclerosis [J].
Paavilainen, T. ;
Kurki, T. ;
Parkkola, R. ;
Farkkila, M. ;
Salonen, O. ;
Dastidar, P. ;
Elovaara, I. ;
Airas, L. .
EUROPEAN JOURNAL OF NEUROLOGY, 2007, 14 (11) :1216-1221
[29]   Is in utero early-exposure to interferon beta a risk factor for pregnancy outcomes in multiple sclerosis? [J].
Patti, F. ;
Cavallaro, T. ;
Lo Fermo, S. ;
Nicoletti, A. ;
Cimino, V. ;
Vecchio, R. ;
Laisa, P. ;
Zarbo, R. ;
Zappia, M. .
JOURNAL OF NEUROLOGY, 2008, 255 (08) :1250-1253
[30]   Estrogen directly activates AID transcription and function [J].
Pauklin, Siim ;
Scrnandez, Isora V. ;
Bachmann, Gudrun ;
Ramiro, Almudena R. ;
Petersen-Mahrt, Svend K. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (01) :99-111