MOUSE NEUTROPHILS LACK DEFENSINS

被引：182

作者：

EISENHAUER, PB ^{[1
]}

LEHRER, RI ^{[1
]}

机构：

[1] W LOS ANGELES VET ADM HOSP,LOS ANGELES,CA 90073

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 08期

关键词：

D O I：

10.1128/IAI.60.8.3446-3447.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Defensins are broad-spectrum antimicrobial peptides that are abundant in human, rat, and rabbit neutrophils. We now report that neutrophils from nine strains of mice lacked appreciable defensin content. Mice may therefore be imperfect experimental surrogates for humans or rats in models of infection in which neutrophil function is significant.

引用

页码：3446 / 3447

页数：2

共 16 条

[11]

OUELLETTE AJ, 1990, J BIOL CHEM, V265, P9831

[12] PURIFICATION, PRIMARY STRUCTURE, AND ANTIMICROBIAL ACTIVITIES OF A GUINEA-PIG NEUTROPHIL DEFENSIN [J].