IMMUNOCHEMICAL QUANTITATION OF FATTY ACID-BINDING PROTEINS - TISSUE DISTRIBUTION OF LIVER AND HEART FABP TYPES IN HUMAN AND PORCINE TISSUES

被引：59

作者：

PAULUSSEN, RJA ^{[1
]}

VANMOERKERK, HTB ^{[1
]}

VEERKAMP, JH ^{[1
]}

机构：

[1] CATHOLIC UNIV NIJMEGEN, DEPT BIOCHEM, NIJMEGEN, NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1990年 / 22卷 / 04期

关键词：

D O I：

10.1016/0020-711X(90)90142-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Antisera against heart and liver fatty acid-binding proteins (FABPs) were used in enzyme-linked immunosorbent assay to study the cross-reactivity between these FABP types of man, pig and rat, and to assess their tissue distribution in man and pig. 2. 2. No cross-reactivities were found of heart FABPs with anti-liver FABP sera and vice versa. With the liver FABPs, marked species differences were found, but the three proteins are clearly related. Human and pig heart FABP are immunochemically closer related to each other than to this protein from rat heart. 3. 3. The tissue distribution of the heart and liver FABP types is similar in man, pig and rat. Liver FABP is only found in liver and intestine, and heart FABP is present in heart, skeletal muscle, kidney, lung, brain and placenta. 4. 4. Cardiac FABP is also found in cultured human and rat endothelial cells. 5. 5. The FABP content of human and pig liver is comparable to that of rat liver, but the tissue concentrations of heart FABP are lower in man and pig than in rat. When the latter values are expressed relative to the FABP content in heart, analogous distribution patterns are observed in man, pig and rat. © 1990.

引用

页码：393 / 398

页数：6

共 51 条

[31] FATTY ACID-BINDING CAPACITY OF CYTOSOLIC PROTEINS OF VARIOUS RAT-TISSUES - EFFECT OF POSTNATAL-DEVELOPMENT, STARVATION, SEX, CLOFIBRATE FEEDING AND LIGHT CYCLE [J].

PAULUSSEN, RJA ;

JANSEN, GPM ;

VEERKAMP, JH .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 877 (03) :342-349

[32] IMMUNOCHEMICAL QUANTITATION OF FATTY-ACID-BINDING PROTEINS .1. TISSUE AND INTRACELLULAR-DISTRIBUTION, POSTNATAL-DEVELOPMENT AND INFLUENCE OF PHYSIOLOGICAL CONDITIONS ON RAT-HEART AND LIVER FABP [J].

PAULUSSEN, RJA ;

GEELEN, MJH ;

BEYNEN, AC ;

VEERKAMP, JH .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 1001 (02) :201-209

[33]

PAULUSSEN RJA, 1990, SUBCELLULAR BIOCH IN, V16

[34] THE BINDING-AFFINITY OF FATTY ACID-BINDING PROTEINS FROM HUMAN, PIG AND RAT-LIVER FOR DIFFERENT FLUORESCENT FATTY-ACIDS AND OTHER LIGANDS [J].

PEETERS, RA ;

GROEN, MAPMI ;

DEMOEL, MP ;

VANMOERKERK, HTB ;

VEERKAMP, JH .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1989, 21 (04) :407-&

[35] THE FATTY ACID-BINDING PROTEIN FROM HUMAN SKELETAL-MUSCLE [J].

PEETERS, RA ;

GROEN, MAI ;

VEERKAMP, JH .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1989, 274 (02) :556-563

[36] PURIFICATION AND CHARACTERIZATION OF FATTY-ACID BINDING-PROTEIN IN MAMMALIAN LUNG [J].

RIAZULHAQ ;

SHRAGO, E ;

CHRISTODOULIDES, L ;

KETTERER, B .

EXPERIMENTAL LUNG RESEARCH, 1985, 9 (1-2) :43-55

[37]

SAID B, 1985, FED PROC, V44, P1415

[38] HYPERTENSION INDUCES TISSUE-SPECIFIC GENE SUPPRESSION OF A FATTY-ACID BINDING-PROTEIN IN RAT AORTA [J].

SARZANI, R ;

CLAFFEY, KP ;

CHOBANIAN, AV ;

BRECHER, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (20) :7777-7781

[39] WHY FATTY-ACIDS FLOW IN CELL-MEMBRANES [J].

SCOW, RO ;

BLANCHETTEMACKIE, EJ .

PROGRESS IN LIPID RESEARCH, 1985, 24 (03) :197-&

[40]

SHIELDS HM, 1986, J LIPID RES, V27, P549

← 1 2 3 4 5 6 →