AGE-RELATED-CHANGES IN TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF THE DOPAMINERGIC SYSTEM

被引：14

作者：

ROTH, GS ^{[1
]}

JOSEPH, JA ^{[1
]}

机构：

[1] TUFTS UNIV,USDA ARS,HNRCA,BOSTON,MA 02111

来源：

LIFE SCIENCES | 1994年 / 55卷 / 25-26期

关键词：

AGING; DOPAMINE RECEPTORS; TRANSCRIPTION; TRANSLATION NEURONAL LOSS;

D O I：

10.1016/0024-3205(94)00383-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Loss of striatal dopamine receptors is a major cause of decreased motor control and a robust biomarker of aging. Mechanisms of receptor loss include both neuronal death and decreased expression of receptor genes at the transcriptional and translational levels.

引用

页码：2031 / 2035

页数：5

共 17 条

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