GAMMA-GLOBULIN PROPHYLAXIS TO REDUCE POSTTRANSFUSION NON-A, NON-B HEPATITIS AFTER CARDIAC-SURGERY WITH CARDIOPULMONARY BYPASS

被引:5
作者
ALKHAJA, N
ROBERTS, DG
BELBOUL, A
LOPERE, V
BERGMAN, P
RADBERG, G
HERMODSSON, S
OLSSON, RG
机构
[1] GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT MED MICROBIOL,S-41345 GOTHENBURG,SWEDEN
[2] GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT MED,S-41345 GOTHENBURG,SWEDEN
来源
SCANDINAVIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | 1991年 / 25卷 / 01期
关键词
NON-A; NON-B HEPATITIS; IMMUNE SERUM GLOBULIN; CARDIAC SURGERY; CARDIOPULMONARY BYPASS;
D O I
10.3109/14017439109098076
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A prospective, randomized study of immune serum globulin (ISG) for prevention of post-transfusion hepatitis was performed on 196 patients (100 controls without gammaglobulin or placebo and 96 who received ISG) undergoing valve replacement or coronary artery bypass with extracorporeal circulation. The dose of ISG was 2 ml i.m. at premedication and 2 ml i.m. on postoperative day 3. Probable non-A, non-B hepatitis developed postoperatively in ten of the 100 controls and two of the 96 in the ISG group. Two ISG patients and three controls with non-A, non-B hepatitis still have increased serum aminotransferase values after 3-5 years, but liver biopsy revealed hepatitis, which histologically was very mild, in only two control and two ISG patients. Low-dose gamma globulin thus reduced the incidence of acute, probable non-A, non-B hepatitis in cardiac surgery with cardiopulmonary bypass.
引用
收藏
页码:7 / 12
页数:6
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