A ROLE FOR THE MINERALOCORTICOID RECEPTOR IN A RAPID AND TRANSIENT SUPPRESSION OF HIPPOCAMPAL 5-HT1A RECEPTOR MESSENGER-RNA BY CORTICOSTERONE

被引：57

作者：

MEIJER, OC

DEKLOET, ER

机构：

[1] Leiden/Amsterdam Center for Drug Research, Division of Medical Pharmacology, Sylvius Laboratories, Leiden, 2300 RA

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 1995年 / 7卷 / 08期

关键词：

GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; HIPPOCAMPUS; SEROTONIN; RAT;

D O I：

10.1111/j.1365-2826.1995.tb00804.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The interaction between corticosterone and hippocampal 5-HT1A receptor mRNA expression was investigated in male rats. Two days after adrenalectomy, 5-HT1A receptor mRNA was increased in the granule cell layer of the dentate gyrus, injection of corticosterone led to a significant dose-dependent and transient suppression of 5-HT1A receptor mRNA. The effect of a low dose of corticosterone (50 mu g/kg) could be blocked by RU 28318, a specific mineralocorticoid receptor antagonist, but not by RU 38486, a glucocorticoid antagonist. The effect of a higher dose of corticosterone (300 mu g/kg) could be partially blocked by RU 28318, whereas there was no additional effect of RU 38486. These results point to a stringent regulation of hippocampal 5-HT1A receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor.

引用

页码：653 / 657

页数：5

共 23 条

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