INCREASED SERUM ALANINE AMINOTRANSFERASE ACTIVITY ASSOCIATED WITH MUSCLE NECROSIS IN THE DOG

被引：73

作者：

VALENTINE, BA

BLUE, JT

SHELLEY, SM

COOPER, BJ

机构：

[1] Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 1990年 / 4卷 / 03期

关键词：

D O I：

10.1111/j.1939-1676.1990.tb00886.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Serum activity of alanine aminotransferase (ALT) was consistently increasedin dogs with canine X‐linked muscular dystrophy (CXMD), a primary myopathy characterized by profound and on‐going skeletal muscle necrosis. In order to determine whether the ALT was of liver origin, serum activity of creatine kinase (CK), aspartate aminotransferase (AST), ALT, and sorbitol dehydrogenase (SDH) obtained from dystrophic dogs was compared with enzyme activity present in clinically normal dogs. In dystrophic dogs at all ages tested, serum activity of CK, AST, and ALT was increased, and significant increases were present in dogs four weeks or older. In contrast, SDH activity in dystrophic dogs was not statistically different from values in clinically normal dogs. Ultrastructural examination of liver tissue revealed no evidence of hepatic degeneration in dystrophic dogs. It was concluded that increased serum activity of ALT in the dog may be associated with severe skeletal muscle degeneration, without concurrent hepatocellular necrosis. (Journal of Veterinary Internal Medicine 1990; 4:140–143) Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：140 / 143

页数：4

共 19 条

[11]

Boyd JW., Serum enzymes in the diagnosis of disease in man and animals, J Comp Pathol, 98, pp. 381-404, (1988)

[12]

Dooley JF, Turnquist LJ, Racich L., Kinetic determination of serum sorbitol dehydrogenase activity with a centrifugal analyzer, Clin Chem, 25, pp. 2026-2029, (1979)

[13]

Keller P., Enzyme activities in the dog: Tissue analyses, plasma values, and intracellular distribution, Am J Vet Res, 42, pp. 575-582, (1981)

[14]

Zinkl JG, Bush RM, Cornelius CE, Et al., Comparative studies on plasma and tissue sorbitol, glutamic, lactic and hydroxybutyric dehydrogenase and transaminase activities in the dog, Res Vet Sci, 12, pp. 211-214, (1971)

[15]

Pennington RJG., Clinical biochemistry of muscular dystrophy, Br Med Bull, 36, pp. 123-126, (1980)

[16]

Jackson MJ, Round JM, Newham DJ, Et al., An examination of some factors influencing creatine kinase in the blood of patients with muscular dystrophy, Muscle Nerve, 10, pp. 15-21, (1987)

[17]

Boyd JW., Serum enzyme changes in lambs with experimentallyinduced acute muscular dystrophy, Res Vet Sci, 5, pp. 419-433, (1964)

[18]

Kornegay JN, Gorgacz EJ, Dawe DL, Et al., Polymyositis in dogs, J Am Vet Med Assoc, 176, pp. 431-438, (1980)

[19]

Valentine BA, Cummings JF, Cooper BJ., Development of Du‐chenne‐type cardiomyopathy: Morphologic studies in a canine model, Am J Pathol, 35, pp. 671-678, (1989)

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