SYNTHESIS OF POTENTIAL AGONISTS AND ANTAGONISTS FOR CENTRAL GLUTAMATE RECEPTORS BY A NOVEL RING SWITCHING PROCESS

被引：44

作者：

BOWLER, AN ^{[1
]}

DOYLE, PM ^{[1
]}

YOUNG, DW ^{[1
]}

机构：

[1] UNIV SUSSEX,SCH CHEM & MOLEC SCI,BRIGHTON BN1 9QJ,E SUSSEX,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 05期

关键词：

D O I：

10.1039/c39910000314

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Heterocyclic derivatives 6 of (S)-glutamic acid, which are structurally related to key central nervous system (CNS) glutamate receptor agonists, are prepared from the aldehyde 9 using a novel reaction in which the pyroglutamate ring is cleaved in concert with formation of the new heterocyclic ring.

引用

页码：314 / 316

页数：3

共 16 条

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