THE TRANSPORT OF NA+ AND K+ IONS THROUGH PHOSPHOLIPID-BILAYERS MEDIATED BY THE ANTIBIOTICS SALINOMYCIN AND NARASIN STUDIED BY NA-23-NMR AND K-39-NMR SPECTROSCOPY

被引:44
作者
RIDDELL, FG
TOMPSETT, SJ
机构
[1] Department of Chemistry, The University of St Andrews, St Andrews, Scotland
关键词
Antibiotic; Ion transport; Ionophore; Narasin; NMR; !sup]23[!/sup]Na-; !sup]39[!/sup]K-; Phospholipid bilayer; Salinomycin;
D O I
10.1016/0005-2736(90)90225-D
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Addition of the ionophoric antibiotics salinomycin or narasin to preparations of large unilamellar vesicles made from egg yolk phosphatidylcholine in sodium or potassium chloride solutions gives rise to dynamic effects in the 23Na- and 39K-NMR spectra. The dynamic spectra arise from the ionophore-mediated transport of the metal ions through the membrane. The kinetics of the transport are followed as a function of the concentrations of ionophore and the metal ion and are compatible in all cases with a model in which one ionophore molecule transports one metal ion. For both ionophores the transport of potassium ions is appreciably faster than that of sodium and in both cases the rate-limiting step for sodium transport is dissociation of the ionophore-metal complex. Assuming dissociation to be rate limiting in all four cases it is shown that the transport rate differences between the pairs of complexes of each metal arise solely from differences in the rates of formation. The stability constants for ionophore-metal complex formation in the membrane/water interface are evaluated. © 1990.
引用
收藏
页码:193 / 197
页数:5
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