ORCHIECTOMY UP-REGULATES RABBIT PROSTATE PERIPHERAL BENZODIAZEPINE RECEPTORS

被引：8

作者：

BATRA, S ^{[1
]}

ALENFALL, J ^{[1
]}

机构：

[1] KABI PHARMACIA AB,ONCOL,LUND,SWEDEN

来源：

LIFE SCIENCES | 1992年 / 51卷 / 15期

关键词：

D O I：

10.1016/0024-3205(92)90358-V

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of orchiectomy on peripheral benzodiazepine receptors (PBZr) in the rabbit prostate was studied. The mean PBZr density in the mitochondrial fraction isolated from prostates of intact (non castrated) rabbits was 4066 fmol/mg protein which following castration increased to 7236 fmol/mg protein (p<0.005). The apparent dissociation constant (K(D)) of prostatic PBZr was higher in castrated rabbits (4.2 nM) than in intact animals (2.7 nM). These data suggest a role of androgen in the regulation of prostatic PBZr.

引用

页码：1211 / 1215

页数：5

共 17 条

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