USE OF MU-CONOTOXIN GIIIA FOR THE STUDY OF SYNAPTIC TRANSMISSION AT THE FROG NEUROMUSCULAR-JUNCTION

被引：10

作者：

SOSA, MA

ZENGEL, JE

机构：

[1] UNIV FLORIDA,COLL MED,DEPT NEUROSCI,POB 100244,GAINESVILLE,FL 32610

[2] UNIV FLORIDA,COLL MED,DEPT NEUROSURG,GAINESVILLE,FL 32610

[3] VET ADM MED CTR,GAINESVILLE,FL 32602

来源：

NEUROSCIENCE LETTERS | 1993年 / 157卷 / 02期

关键词：

MU-CONOTOXIN GIIIA; CONUS-GEOGRAPHUS; FROG NEUROMUSCULAR JUNCTION; SODIUM CHANNEL; MUSCLE CONTRACTION; TRANSMITTER RELEASE; SYNAPTIC TRANSMISSION;

D O I：

10.1016/0304-3940(93)90745-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have looked at the effect of synthetic mu-conotoxin GIIIA, a selective blocker of muscle Na channels, on various parameters of synaptic transmission at the frog sartorius nerve-muscle preparation. We found that 5 muM mu-conotoxin consistently blocked muscle action potentials, but had no effect on nerve action potentials. The toxin also had no effect on the amplitude or frequency of miniature endplate potentials (MEPPs), on the amplitude or time course of endplate potentials (EPPs), or on stimulation-induced changes in EPP amplitude. The lack of an effect of synthetic mu-conotoxin GIIIA on transmitter release makes this toxin an invaluable tool in the study of neuromuscular transmission under conditions of normal levels of release.

引用

页码：235 / 238

页数：4