EFFECTS OF AMIDATED RAT ISLET AMYLOID POLYPEPTIDE ON GLUCOSE-STIMULATED INSULIN-SECRETION INVIVO AND INVITRO IN RATS

被引：34

作者：

ARRAJAB, A

AHREN, B

机构：

[1] UNIV LUND,DEPT PHARMACOL,SOLVEGATAN 10,S-22362 LUND,SWEDEN

[2] UNIV LUND,DEPT SURG,S-22362 LUND,SWEDEN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 192卷 / 03期

关键词：

ISLET AMYLOID POLYPEPTIDE; INSULIN SECRETION; (INVIVO); (INVITRO); (RAT);

D O I：

10.1016/0014-2999(91)90239-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Amidated rat islet amyloid polypeptide (IAPP) is a constituent of secretory granules in islet B-cells. We examined its influence on glucose-stimulated insulin secretion in rats. In vivo, intravenous infusion of IAPP (68 pmol/min) did not affect glucose-stimulated insulin secretion. In vitro, IAPP slightly inhibited glucose (8.3 mM)-stimulated insulin secretion from isolated rat islets at the high dose level of 10(-5) M but not at the lower dose levels. We conclude that the IAPP is not involved in the normal regulation of insulin secretion.

引用

页码：443 / 445

页数：3