ADJUVANT INTRAOPERATIVE PHOTODYNAMIC THERAPY FOR COLORECTAL-CARCINOMA - A CLINICAL-STUDY

被引：26

作者：

ALLARDICE, JT

ABULAFI, AM

GRAHN, MF

WILLIAMS, NS

机构：

[1] Surgical Unit, Royal London Hospital, Whitechapel, London

来源：

SURGICAL ONCOLOGY-OXFORD | 1994年 / 3卷 / 01期

关键词：

ADJUVANT THERAPY; COLONIC NEOPLASMS; INTRAOPERATIVE PERIOD; OPERATIVE SURGERY; PHOTODYNAMIC THERAPY; RECTAL NEOPLASMS;

D O I：

10.1016/0960-7404(94)90018-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The local recurrence rate of colorectal carcinoma after surgery is unacceptable in most series, and adjuvant therapies have made only a small impact on this. There is experimental evidence that adjuvant intraoperative photodynamic therapy (AIOPDT) may be effective. AIOPDT involves systemically photosensitizing the patient preoperatively with a drug (HpD) which relatively localizes to tumour and is activated using visible light. At operation the resected tumour bed is illuminated with a predetermined uniform light energy density to eradicate microscopic tumour deposits left at the lateral resection margin. We have previously investigated technical and biological factors leading to this clinical trial. Seventeen patients have received AIOPDT in a potentially effective dose, and safety and technical matters have been investigated. Cutaneous phototoxicity occurred in 3 patients. Three patients had anastomotic breakdown, none considered attributable to PDT. The intraoperative technique was a practical option. AIOPDT carried a low patient morbidity and should be investigated in prospective clinical trials to determine if local recurrence rates can be decreased.

引用

页码：1 / 10

页数：10

共 48 条

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