THE HUMAN TYROSINE AMINOTRANSFERASE GENE MAPPED TO THE LONG ARM OF CHROMOSOME-16 (REGION 16Q22-]Q24) BY SOMATIC-CELL HYBRID ANALYSIS AND INSITU HYBRIDIZATION

被引：36

作者：

BARTON, DE ^{[1
]}

YANGFENG, TL ^{[1
]}

FRANCKE, U ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, DEPT HUMAN GENET, 333 CEDAR ST, NEW HAVEN, CT 06510 USA

来源：

HUMAN GENETICS | 1986年 / 72卷 / 03期

关键词：

D O I：

10.1007/BF00291881

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Tyrosine aminotransferase (TAT; EC 2.6.1.5) is a liver enzyme involved in amino acid metabolism and gluconeogenesis. Low levels of TAT have been implicated in several inherited disorders, particularly tyrosinemia II (Richner-Hanhart syndrome). We have determined the chromosomal location of the human TAT gene by Southern blot hybridization analysis of DNAs from 18 human .times. rodent hybrid cell lines, using a rat cDNA probe. The results indicate that the TAT gene maps to chromosome 16. Analysis of two hybrids containing a rearranged chromosome 16 allowed assignment of the TAT locus to 16q22 .fwdarw. 24. In situ hybridization to human metaphase chromosomes confirmed this regional assignment.

引用

页码：221 / 224

页数：4