DETECTION OF (1-3)-BETA-D-GLUCAN IN A RAT MODEL OF ASPERGILLOSIS

被引：27

作者：

MITSUTAKE, K ^{[1
]}

KOHNO, S ^{[1
]}

MIYAZAKI, T ^{[1
]}

YAMAMOTO, Y ^{[1
]}

YANAGIHARA, K ^{[1
]}

KAKEYA, H ^{[1
]}

HASHIMOTO, A ^{[1
]}

KOGA, H ^{[1
]}

HARA, K ^{[1
]}

机构：

[1] NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 2,NAGASAKI 852,JAPAN

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 1995年 / 9卷 / 02期

关键词：

ASPERGILLOSIS; BETA-GLUCAN; SERODIAGNOSIS;

D O I：

10.1002/jcla.1860090208

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The G test containing factor G, fractioned from the Limulus lysate, was used to detect (1-3)-beta-D-glucan in a rat model of aspergillosis. Aspergillus fumigatus strain MF-13, 1x10(4) conidia, were inoculated transtracheally into rats treated with cortisone acetate (100 mg/kg) and fed a low-protein (8%) diet. Increased serum (1-3)-beta-D-glucan was found on the sixth day after inoculation in concentrations of 370+/-178 pg/ml (mean +/-SD) in untreated controls, and 154 +/- 43 pg/ml in rats treated with 0.5 mg/kg of amphotericin B. On day 11 (1-3)-beta-D-glucan concentrations were 2,590+/-2,940 pg/ml and 448+/-442 pg/ml, respectively. The elevation in levels of (1-3)-beta-D-glucan increased in correlation with the elevation of galactomannan antigen titers; (1-3)-beta-D-glucan is thus measurable during experimental aspergillosis in rats. (C) 1995 Wiley-Liss, Inc.

引用

页码：119 / 122

页数：4

共 27 条

[21] GALACTOMANNAN ANTIGENEMIA IN INVASIVE ASPERGILLOSIS [J].

REISS, E ;

LEHMANN, PF .

INFECTION AND IMMUNITY, 1979, 25 (01) :357-365

[22]

SHAFFER PJ, 1979, J INFECT DIS, V3, P313

[23] SERODIAGNOSIS OF INVASIVE ASPERGILLOSIS IN PATIENTS WITH HEMATOLOGIC MALIGNANCY - VALIDATION OF THE ASPERGILLUS-FUMIGATUS ANTIGEN RADIOIMMUNOASSAY [J].

TALBOT, GH ;

WEINER, MH ;

GERSON, SL ;

PROVENCHER, M ;

HURWITZ, S .

JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (01) :12-27

[24] ACTIVATION OF A LIMULUS COAGULATION FACTOR-G BY (1-]3)-BETA-D-GLUCANS [J].

TANAKA, S ;

AKETAGAWA, J ;

TAKAHASHI, S ;

SHIBATA, Y ;

TSUMURAYA, Y ;

HASHIMOTO, Y .

CARBOHYDRATE RESEARCH, 1991, 218 :167-174

[25] DETECTION OF CIRCULATING GALACTOMANNAN BY PASTOREX ASPERGILLUS IN EXPERIMENTAL INVASIVE ASPERGILLOSIS [J].

VANCUTSEM, J ;

MEULEMANS, L ;

VANGERVEN, F ;

STYNEN, D .

MYCOSES, 1990, 33 (02) :61-69

[26]

WEINER MH, 1979, J LAB CLIN MED, V93, P111

[27] ANTIGEN-DETECTION IN THE DIAGNOSIS OF INVASIVE ASPERGILLOSIS - UTILITY IN CONTROLLED, BLINDED TRIALS [J].

WEINER, MH ;

TALBOT, GH ;

GERSON, SL ;

FILICE, G ;

CASSILETH, PA .

ANNALS OF INTERNAL MEDICINE, 1983, 99 (06) :777-782

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