INOCULATED MOUSE MODEL OF PNEUMOCYSTIS-CARINII INFECTION

被引：30

作者：

BARTLETT, MS ^{[1
]}

QUEENER, SF ^{[1
]}

DURKIN, MM ^{[1
]}

SHAW, MA ^{[1
]}

SMITH, JW ^{[1
]}

机构：

[1] INDIANA UNIV,SCH MED,DEPT PHARMACOL & TOXICOL,INDIANAPOLIS,IN 46202

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 1992年 / 15卷 / 02期

关键词：

D O I：

10.1016/0732-8893(92)90036-S

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A transtracheally inoculated mouse model of Pneumocystis carinii has been developed using BALB/c mice. The advantage of this strain of mice include that they are widely available, inexpensive, and were not infected with Pneumocystis before inoculation. Inoculated mice that were not treated had a mean infectivity score of 4.1 compared with inoculated mice treated with the effective anti-Pneumocystis drug combination of trimethoprim plus sulfamethoxazole, which had a mean infectivity score of 0.1, an approximately 4 log difference. The inoculated BALB/c mouse provides a model to serve as a valuable addition to rat models currently used, providing a source of organisms from a different host for cross-species comparisons and for studies of drug efficacy for therapy and prophylaxis. The inoculated mouse is especially cost effective and allows testing of compounds in short supply.

引用

页码：129 / 134

页数：6