THE ROLE OF AN ENDOGENOUS NONHEME IRON IN MICROSOMAL REDOX REACTIONS

Microsomal membranes contain a nonheme iron which serves in vitro for the peroxidation of unsaturated lipids or the oxidation of several other chemicals. These redox reactions are reviewed in light of a recent identification of two or more iron-binding proteins in the microsomal milieu. Indirect evidence that the microsomal iron might serve in vivo for the synthesis of heme iron is also presented and discussed. Consistent with this, the newly identified iron proteins not only participate in redox reactions but also release their bound iron upon incubation with certain intermediates of heme synthesis. © 1992.