DIABETES AFFECTS ALPHA-CRYSTALLIN CHAPERONE FUNCTION

被引：38

作者：

CHERIAN, M ^{[1
]}

ABRAHAM, EC ^{[1
]}

机构：

[1] MED COLL GEORGIA,DEPT BIOCHEM & MOLEC BIOL,AUGUSTA,GA 30912

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 212卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1954

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

rn vitro glycation was previously shown to influence alpha-crystallin chaperone function. In the present study we show that this function is compromised in diabetes. The alpha(H), alpha(L) and the total alpha fractions were isolated by gel permeation chromatography from the water - soluble protein of streptozotocin - diabetic as well as age-matched normal rats. Based on the beta(L)-crystallin thermal denaturation assay the chaperone function was significantly decreased in the diabetic rats. (C) 1995 Academic Press, Inc.

引用

页码：184 / 189

页数：6

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