ANTAGONIZING EFFECT OF MORPHINE ON THE MOBILITY AND PHAGOCYTIC-ACTIVITY OF INVERTEBRATE IMMUNOCYTES

被引：21

作者：

OTTAVIANI, E ^{[1
]}

FRANCHINI, A ^{[1
]}

SONETTI, D ^{[1
]}

STEFANO, GB ^{[1
]}

机构：

[1] SUNY COLL OLD WESTBURY,NEUROSCI RES INST,OLD WESTBURY,NY 11568

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 276卷 / 1-2期

关键词：

MORPHINE; LIPOPOLYSACCHARIDE; PHAGOCYTOSIS; INVERTEBRATE IMMUNOCYTE;

D O I：

10.1016/0014-2999(95)00008-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study we have demonstrated that lipopolysaccharide (LPS) acts as an activator in the immunocytes of molluscs Planorbarius corneus, Mytilus edulis, and the insect Leucophaea maderae. This stimulatory effect, demonstrated by cellular conformational changes, is concentration- and time-dependent, and is antagonized by morphine. The inhibitory effect of morphine carl be counteracted by naloxone. Morphine inhibitory action on immunocyte activity is also demonstrated by a decrease in the phagacytic activity. These data suggest that the downregulation of morphine is not limited to vertebrates but is also present in invertebrates.

引用

页码：35 / 39

页数：5

共 22 条

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