QUANTIFYING DRUG-INDUCED CHANGES IN PARKINSONIAN RIGIDITY USING AN INSTRUMENTAL MEASURE OF ACTIVATED STIFFNESS

被引：25

作者：

CALIGIURI, MP

GALASKO, DR

机构：

[1] DEPT VET AFFAIRS MED CTR,NEUROL SERV,SAN DIEGO,CA 92161

[2] UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,SAN DIEGO,CA 92103

[3] UNIV CALIF SAN DIEGO,DEPT NEUROSCI,SAN DIEGO,CA 92103

来源：

CLINICAL NEUROPHARMACOLOGY | 1992年 / 15卷 / 01期

关键词：

RIGIDITY; PARKINSONISM; NEUROLEPTICS; L-DOPA; INSTRUMENTATION;

D O I：

10.1097/00002826-199202000-00001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We review the literature on quantifying parkinsonian rigidity and present data from 124 subjects to demonstrate the clinical utility of activated stiffness to model rigidity. This method eliminates many of the confounding variables associated with the subjective assessment of rigidity. This 5-min computer-assisted procedure was highly reliable and sensitive to pharmacologic influences that produce and reduce parkinsonian rigidity.

引用

页码：1 / 12

页数：12

共 40 条

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