INTERLEUKIN-4 INHIBITS THE DIFFERENTIATION OF MOUSE MYELOID-LEUKEMIA M1-CELLS INDUCED BY DEXAMETHASONE, D-FACTOR LEUKEMIA INHIBITORY FACTOR AND INTERLEUKIN-6, BUT NOT BY 1-ALPHA,25-DIHYDROXYVITAMIN-D3

被引：9

作者：

KASUKABE, T

OKABEKADO, J

HONMA, Y

HOZUMI, M

机构：

[1] Department of Chemotherapy, Saitama Cancer Center Research Institute, Saitama, 362, Inamachi

来源：

FEBS LETTERS | 1991年 / 291卷 / 02期

关键词：

INTERLEUKIN-4; DIFFERENTIATION; GROWTH; MYELOID LEUKEMIA CELL; M1-CELL;

D O I：

10.1016/0014-5793(91)81278-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of interleukin-4(IL-4) on the growth and differentiation of mouse myeloid leukemia M1 cells induced by various differentiation inducers were investigated. IL-4 alone did not have any significant effect on the growth or differentiation of M1 cells, but inhibited their differentiation induced by dexamethasone, D-factor/leukemia inhibitory factor, or interleukin 6. IL-4 also restored the proliferation of M1 cells after growth inhibition during their induction of differentiation by inducers. In contrast, IL-4 enhanced inhibition of growth and induction of differentiation of M1 cells by 1-alpha,25-dihydroxyvitamin D3. These results indicate that modulation of differentiation of M1 cells by IL-4 depends on the differentiation inducer.

引用

页码：181 / 184

页数：4

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