EXPERIMENTAL HEPATOCELLULAR-CARCINOMA - MR RECEPTOR IMAGING

被引:28
作者
REIMER, P
WEISSLEDER, R
BRADY, TJ
YEAGER, AE
BALDWIN, BH
TENNANT, BC
WITTENBERG, J
机构
[1] MASSACHUSETTS GEN HOSP NMR CTR, 13TH ST, BLDG 149, BOSTON, MA 02129 USA
[2] MASSACHUSETTS GEN HOSP, DEPT RADIOL, BOSTON, MA 02114 USA
[3] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
[4] CORNELL UNIV, COLL VET MED, ITHACA, NY 14853 USA
关键词
CONTRAST MEDIA; COMPARATIVE STUDIES; LIVER NEOPLASMS; MR STUDIES; MAGNETIC RESONANCE (MR); CONTRAST ENHANCEMENT; NEOPLASMS; EXPERIMENTAL;
D O I
10.1148/radiology.180.3.1871273
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Relaxation time measurements and magnetic resonance (MR) imaging were performed in three different animal models of hepatocellular carcinoma (HCC). After intravenous administration of asialoglycoprotein-directed arabinogalactan-stabilized ultrasmall superparamagnetic iron oxide (10-mu-mol Fe/kg receptor agent), T2 of normal liver decreased from 41.6 msec +/- 1.0 to 19.4 msec +/- 1.7 (P < .05) in rats. T2 of HCC implanted in normal liver or liver with chronic hepatitis was essentially unchanged. These results were similar to those obtained by administration of a reticuloendothelial cell-directed conventional iron oxide; however, the required dose of receptor agent was lower. MR imaging in a wood-chuck model of virally induced HCC confirmed the distribution of the hepatocyte-directed agent to regions of functioning and differentiated hepatocytes but not to malignant tumor tissue. The results suggest that MR receptor imaging may play a role in the differentiation between primary liver tumor and functional liver tissue such as that in normal liver hepatitis or regenerating nodules.
引用
收藏
页码:641 / 645
页数:5
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