SELECTIVE RESISTANCE OF TACHYKININ-RESPONSIVE CHOLINERGIC NEURONS IN THE QUINOLINIC ACID LESIONED NEOSTRIATUM

被引：14

作者：

ARENAS, E ^{[1
]}

PEREZNAVARRO, E ^{[1
]}

ALBERCH, J ^{[1
]}

MARSAL, J ^{[1
]}

机构：

[1] UNIV BARCELONA,HOSP BELLVITGE,FAC MED,DEPT BIOL CELLULAR & ANAT PATOL,BARCELONA 7,SPAIN

来源：

BRAIN RESEARCH | 1993年 / 603卷 / 02期

关键词：

STRIATUM; QUINOLINATE EXCITOTOXICITY; ENDOGENOUS ACETYLCHOLINE RELEASE; TACHYKININ; GLUTAMATE;

D O I：

10.1016/0006-8993(93)91254-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have studied changes on endogenous acetylcholine (ACh) release evoked by different agents from rat neostriatal slices after quinolinic acid (QA) injections. QA lesions induced a biphasic decrease on ACh release evoked by 1 muM glutamate and 50 mM KCl. ACh release evoked by selective tachykinin agonists was only significantly decreased by 250 nmol QA. These results suggest the presence of different functional cholinergic cell populations, with tachykinin-responsive cholinergic neurons selectively spared.

引用

页码：317 / 320

页数：4

共 31 条

[1] EXCITATORY AMINO-ACIDS RELEASE ENDOGENOUS ACETYLCHOLINE FROM RAT STRIATAL SLICES - REGULATION BY GAMMA-AMINOBUTYRIC-ACID
ALBERCH, J
ARENAS, E
ARROYOS, RS
MARSAL, J
[J]. NEUROCHEMISTRY INTERNATIONAL, 1990, 17 (01) : 107 - 116
[2] MODULATION OF THE ENDOGENOUS ACETYLCHOLINE-RELEASE FROM RAT STRIATAL SLICES
ALBERCH, J
MARSAL, J
SOLSONA, C
[J]. BRAIN RESEARCH, 1985, 346 (02) : 353 - 356
[3] HUNTINGTONS-DISEASE - CHANGES IN TACHYKININ CONTENT IN POSTMORTEM BRAINS
ARAI, H
EMSON, PC
CARRASCO, LH
[J]. ANNALS OF NEUROLOGY, 1987, 22 (05) : 587 - 594
[4] DOPAMINERGIC SYSTEM MEDIATES ONLY DELTA-OPIATE INHIBITION OF ENDOGENOUS ACETYLCHOLINE-RELEASE EVOKED BY GLUTAMATE FROM RAT STRIATAL SLICES
ARENAS, E
ALBERCH, J
MARSAL, J
[J]. NEUROSCIENCE, 1991, 42 (03) : 707 - 714
[5] GABA-A AND GABA-B ANTAGONISTS PREVENT THE OPIOID INHIBITION OF ENDOGENOUS ACETYLCHOLINE-RELEASE EVOKED BY GLUTAMATE FROM RAT NEOSTRIATAL SLICES
ARENAS, E
MARSAL, J
ALBERCH, J
[J]. NEUROSCIENCE LETTERS, 1990, 120 (02) : 201 - 204
[6] ARENAS E, 1991, J NEUROSCI, V11, P2332
[7] BAKER R, 1991, NEUROPEPTIDES, V29, P73
[8] REPLICATION OF THE NEUROCHEMICAL CHARACTERISTICS OF HUNTINGTONS-DISEASE BY QUINOLINIC ACID
BEAL, MF
KOWALL, NW
ELLISON, DW
MAZUREK, MF
SWARTZ, KJ
MARTIN, JB
[J]. NATURE, 1986, 321 (6066) : 168 - 171
[9] BEAL MF, 1988, J NEUROSCI, V8, P3901
[10] DIFFERENTIAL SENSITIVITY OF NEUROPEPTIDE-Y, SOMATOSTATIN AND NADPH-DIAPHORASE CONTAINING NEURONS IN RAT CORTEX AND STRIATUM TO QUINOLINIC ACID
BOEGMAN, RJ
PARENT, A
[J]. BRAIN RESEARCH, 1988, 445 (02) : 358 - 362

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