REGIOSELECTIVE SYNTHESIS OF 1,7-DIPROTECTED 1,4,7,10-TETRAAZACYCLODODECANE AND PREPARATION OF A DIALCOHOL DICARBOXYLIC MACROCYCLIC LIGAND

被引：46

作者：

DUMONT, A ^{[1
]}

JACQUES, V ^{[1
]}

PENG, QX ^{[1
]}

DESREUX, JF ^{[1
]}

机构：

[1] UNIV LIEGE,B-4000 SART,BELGIUM

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)73077-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of 1,4,7,10-tetraazacyclododecane with p-toluenesulfonyl chloride in pyridine or with diethyl phosphite and CCl4 in a water/CH2Cl2 mixture yields selectively the 1,7-diprotected regioisomer. The 1,7-diprotected tetraaza cycles are interesting starting materials, for instance for the preparation of 4,10-bis(2'-hydroxyethyl)-1,7-bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane.

引用

页码：3707 / 3710

页数：4

共 17 条

[1] ATKINS TJ, 1978, Patent No. 4085106
[2] SYNTHESIS OF 2,3,5,6-TETRAHYDRO-1H,4H,11CH-3A,6A,11B-TRIAZABENZ[DE] ANTHRACENE (5) AND X-RAY CRYSTAL-STRUCTURE DETERMINATIONS OF (5), HEXAHYDRO-1H,4H,7H,9BH-3A,6A,9A-TRIAZAPHENALENE (1), BENZO[B]-1,5,9-TRIAZADODECANE N,N',N''-TRITOSYLAMIDE, AND OF 1,5,9-TRIAZADODECANE N,N',N''-TRITOSYLAMIDE
BEDDOES, RL
EDWARDS, WD
JOULE, JA
MILLS, OS
STREET, JD
[J]. TETRAHEDRON, 1987, 43 (08) : 1903 - 1920
[3] GENERAL-ROUTE FOR THE SYNTHESIS OF MONO N-ALKYLATED DERIVATIVES OF TETRAAZAMACROCYCLES
BERNARD, H
YAOUANC, JJ
CLEMENT, JC
ABBAYES, HD
HANDEL, H
[J]. TETRAHEDRON LETTERS, 1991, 32 (05) : 639 - 642
[4] HIGHLY STABLE LANTHANIDE MACROCYCLIC COMPLEXES - IN SEARCH OF NEW CONTRAST AGENTS FOR NMR IMAGING
DESREUX, JF
BARTHELEMY, PP
[J]. NUCLEAR MEDICINE AND BIOLOGY, 1988, 15 (01): : 9 - 15
[5] NUCLEAR MAGNETIC-RESONANCE AND POTENTIOMETRIC STUDIES OF THE PROTONATION SCHEME OF 2 TETRAAZA TETRAACETIC MACROCYCLES
DESREUX, JF
MERCINY, E
LONCIN, MF
[J]. INORGANIC CHEMISTRY, 1981, 20 (04) : 987 - 991
[6] STOICHIOMETRIC MONO N-FUNCTIONALIZATION OF TETRAAZAMACROCYCLES VIA PHOSPHORYL-PROTECTED INTERMEDIATES
FILALI, A
YAOUANC, JJ
HANDEL, H
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (05): : 560 - 561
[7] SYNTHESIS AND METAL-COMPLEXES OF MONO-N-SUBSTITUTED TETRA-AZAMACROCYCLES
HEDIGER, M
KADEN, TA
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1978, (01) : 14 - 15
[8] GENERAL ROUTES FOR THE SYNTHESIS OF MONO, DI AND TRI-N-SUBSTITUTED DERIVATIVES OF CYCLAM
HELPS, IM
PARKER, D
MORPHY, JR
CHAPMAN, J
[J]. TETRAHEDRON, 1989, 45 (01) : 219 - 226
[9] COORDINATION-COMPOUNDS IN NUCLEAR-MEDICINE
JURISSON, S
BERNING, D
JIA, W
MA, DS
[J]. CHEMICAL REVIEWS, 1993, 93 (03) : 1137 - 1156
[10] UNEXPECTED SELECTIVITY IN THE ALKYLATION OF POLYAZAMACROCYCLES
KRUPER, WJ
RUDOLF, PR
LANGHOFF, CA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (15) : 3869 - 3876

← 1 2 →