CYTOCHROME-P-450 ISOZYME ISOZYME FUNCTIONAL INTERACTIONS AND NADPH-CYTOCHROME-P-450 REDUCTASE CONCENTRATIONS AS FACTORS IN MICROSOMAL METABOLISM OF WARFARIN

被引:77
作者
KAMINSKY, LS
GUENGERICH, FP
机构
[1] VANDERBILT UNIV,MED CTR,SCH MED,DEPT BIOCHEM,NASHVILLE,TN 37232
[2] VANDERBILT UNIV,MED CTR,SCH MED,CTR ENVIRONM TOXICOL,NASHVILLE,TN 37232
来源
EUROPEAN JOURNAL OF BIOCHEMISTRY | 1985年 / 149卷 / 03期
关键词
D O I
10.1111/j.1432-1033.1985.tb08950.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:479 / 489
页数:11
相关论文
共 43 条
[21]  
KAMINSKY LS, 1980, J BIOL CHEM, V255, P85
[22]  
KAWATO S, 1982, J BIOL CHEM, V257, P7023
[23]   STIMULATION OF MICROSOMAL DRUG OXIDATION ACTIVITIES BY INCORPORATION INTO MICROSOMES OF PURIFIED NADPH-CYTOCHROME-C (P-450) REDUCTASE [J].
KITADA, M ;
KUBOTA, K ;
KITAGAWA, H ;
KAMATAKI, T .
JAPANESE JOURNAL OF PHARMACOLOGY, 1979, 29 (06) :877-887
[24]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[25]  
LU AYH, 1968, J BIOL CHEM, V243, P1331
[26]   RESOLUTION AND RECONSTITUTION OF LIVER MICROSOMAL HYDROXYLATION SYSTEM [J].
LU, AYH ;
LEVIN, W .
BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 344 (02) :205-240
[27]  
LU AYH, 1980, PHARMACOL REV, V31, P277
[28]   EVIDENCE FROM CROSS-LINKING AND ROTATIONAL DIFFUSION STUDIES THAT CYTOCHROME-P450 CAN FORM MOLECULAR AGGREGATES IN RABBIT-LIVER MICROSOMAL-MEMBRANES [J].
MCINTOSH, PR ;
KAWATO, S ;
FREEDMAN, RB ;
CHERRY, RJ .
FEBS LETTERS, 1980, 122 (01) :54-58
[29]   STIMULATION OF MICROSOMAL N-DEMETHYLATION BY SOLUBILIZED NADPH-CYTOCHROME C REDUCTASE [J].
MIWA, GT ;
CHO, AK .
LIFE SCIENCES, 1976, 18 (09) :983-988
[30]  
MIWA GT, 1979, J BIOL CHEM, V254, P5695