DETERMINATION OF CYCLOPHOSPHAMIDE IN URINE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：51

作者：

SESSINK, PJM

SCHOLTES, MM

ANZION, RBM

BOS, RP

机构：

[1] Department of Toxicology, Faculty of Medical Sciences, University of Nijmegen, NL-6500 HB Nijmegen

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 616卷 / 02期

关键词：

D O I：

10.1016/0378-4347(93)80404-R

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive gas chromatographic method for the determination of cyclophosphamide in urine is presented. After liquid-liquid extraction with diethyl ether and derivatization with trifluoroacetic anhydride, cyclophosphamide was identified and quantified with mass spectrometry. The method is suitable for the determination of cyclophosphamide at concentrations of more than 0.25 ng/ml, which enables the uptake of cyclophosphamide during occupational activities, such as the preparation and administration of antineoplastic agents in hospitals, to be measured. Simple preparation makes the method appropriate for routine analysis.

引用

页码：333 / 337

页数：5

共 14 条

[1]

DEBRUIJN EA, 1991, HRC-J HIGH RES CHROM, V14, P835

[2] DRUG LEVEL MONITORING - CYTOSTATICS [J].