DESIGN AND SYNTHESIS OF AN ORALLY POTENT HUMAN RENIN INHIBITOR CONTAINING A NOVEL AMINO-ACID, CYCLOHEXYLNORSTATINE

被引：74

作者：

IIZUKA, K

KAMIJO, T

HARADA, H

AKAHANE, K

KUBOTA, T

UMEYAMA, H

KISO, Y

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

[2] KYOTO PHARMACEUT UNIV,DEPT MED CHEM,YAMASHINA KU,KYOTO 607,JAPAN

来源：

关键词：

D O I：

10.1039/c39890001678

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：1678 / 1680

页数：3

共 21 条

[11] IIZUKA K, 1988, PEPTIDE CHEM 1987, P649
[12] RENIN INHIBITORS - IMPROVEMENTS IN THE STABILITY AND BIOLOGICAL-ACTIVITY OF SMALL PEPTIDES CONTAINING NOVEL LEU-VAL REPLACEMENTS
KLEINERT, HD
LULY, JR
MARCOTTE, PA
PERUN, TJ
PLATTNER, JJ
STEIN, H
[J]. FEBS LETTERS, 1988, 230 (1-2) : 38 - 42
[13] KOKUBU T, 1986, HYPERTENSION, V8, P1
[14] LULY JR, 1988, J MED CHEM, V31, P531
[15] INTESTINAL-ABSORPTION OF PEPTIDES
MATTHEWS, DM
[J]. PHYSIOLOGICAL REVIEWS, 1975, 55 (04) : 537 - 608
[16] EQUATION OF STATE CALCULATIONS BY FAST COMPUTING MACHINES
METROPOLIS, N
ROSENBLUTH, AW
ROSENBLUTH, MN
TELLER, AH
TELLER, E
[J]. JOURNAL OF CHEMICAL PHYSICS, 1953, 21 (06) : 1087 - 1092
[17] POTENT NEW INHIBITORS OF HUMAN RENIN
SZELKE, M
LECKIE, B
HALLETT, A
JONES, DM
SUEIRAS, J
ATRASH, B
LEVER, AF
[J]. NATURE, 1982, 299 (5883) : 555 - 557
[18] Szelke M., 1983, PEPTIDES STRUCTURE F, P579
[19] A NEW FORCE-FIELD FOR MOLECULAR MECHANICAL SIMULATION OF NUCLEIC-ACIDS AND PROTEINS
WEINER, SJ
KOLLMAN, PA
CASE, DA
SINGH, UC
GHIO, C
ALAGONA, G
PROFETA, S
WEINER, P
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (03) : 765 - 784
[20] EFFECTS OF A SPECIFIC AND LONG-ACTING RENIN INHIBITOR IN THE MARMOSET
WOOD, JM
GULATI, N
FORGIARINI, P
FUHRER, W
HOFBAUER, KG
[J]. HYPERTENSION, 1985, 7 (05) : 797 - 803