DEVELOPMENT OF HUMAN MAST-CELLS FROM THEIR PROGENITORS

被引：44

作者：

ISHIZAKA, T

MITSUI, H

YANAGIDA, M

MIURA, T

DVORAK, AM

机构：

[1] BETH ISRAEL HOSP,BOSTON,MA 02210

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02210

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 06期

关键词：

D O I：

10.1016/0952-7915(93)90109-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Two types of human mast cells, which are morphologically similar to skin mast cells and lung mast cells, respectively, can be developed from pluripotent stem cells under different culture conditions. The major growth factor for mast-cell development is c-kit ligand, which induces mastocytosis in vivo. However, this cytokine is not sufficient for full maturation of the cells.

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收藏

页码：937 / 943

页数：7

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