ANTIBACTERIAL ACTIVITY OF FLAVANONE ISOLATED FROM SOPHORA-EXIGUA AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS AND ITS COMBINATION WITH ANTIBIOTICS

被引：20

作者：

SATO, M

TSUCHIYA, H

TAKASE, I

KURESHIRO, H

TANIGAKI, S

IINUMA, M

机构：

[1] ASAHI UNIV,SCH DENT,DEPT DENT PHARMACOL,GIFU 50102,JAPAN

[2] NISHIWAKI GEN HOSP,NISHIWAKI,HYOGO 677,JAPAN

[3] GIFU PHARMACEUT UNIV,DEPT PHARMACOGNOSY,GIFU 502,JAPAN

来源：

PHYTOTHERAPY RESEARCH | 1995年 / 9卷 / 07期

关键词：

MRSA; ANTIBACTERIAL ACTIVITY; FLAVANONE; PHYTOALEXIN; ANTIBIOTICS;

D O I：

10.1002/ptr.2650090709

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

5,7,2',4'-Tetrahydroxy-8-lavandulyl-flavanone, isolated from Sophora exigua, completely inhibited the growth of 21 strains of methicillin-resistant Staphylococcus aureus (MRSA) at concentrations of 3.13-6.25 mu g/mL. The anti-MRSA effect was based on bactericidal action. In combinations of the flavanone with vancomycin, minocycline and rifampicin, the fractional inhibitory concentration indices were 0.90, 0.88 and 0.85, respectively, indicating partial synergistic effects with anti-MRSA antibiotics. The proposed flavanone would be a potent phytotherapeutic agent against MRSA infections.

引用

收藏

页码：509 / 512

页数：4

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