QUANTITATION OF A MITOCHONDRIAL-DNA DELETION IN PARKINSONS-DISEASE

被引：85

作者：

MANN, VM

COOPER, JM

SCHAPIRA, AHV

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT PROT & MOLEC BIOL,LONDON NW3 2PF,ENGLAND

[2] INST NEUROL,LONDON WC1N 3BG,ENGLAND

来源：

FEBS LETTERS | 1992年 / 299卷 / 03期

关键词：

NADH COQ1 REDUCTASE; PARKINSONS DISEASE; MITOCHONDRION; MITOCHONDRIAL DNA;

D O I：

10.1016/0014-5793(92)80118-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 5 kilobase deletion in mitochondrial DNA (mtDNA) has been reported to be responsible for the specific complex I deficiency in the substantia nigra (SN) of the Parkinson's disease (PD) brain. We have studied mitochondrial respiratory chain function in the SN from control and PD subjects, and analysed mtDNA, extracted from the same tissues, by Southern blot and the polymerase chain reaction (PCR). Quantitation of the levels of the deletion indicate that it does not contribute to the pathogenesis of PD nor to a complex I deficiency but seems likely to be an age-related observation.

引用

页码：218 / 222

页数：5

共 23 条

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