HUMAN AND RODENT DNA-SEQUENCE COMPARISONS - A MOSAIC MODEL OF GENOMIC EVOLUTION

被引：64

作者：

KOOP, BF

机构：

[1] B.F. Koop is in the Center for Environmental Health-Biology, University of Victoria, Victoria

来源：

TRENDS IN GENETICS | 1995年 / 11卷 / 09期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0168-9525(00)89108-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Three pattern of DNA sequence conservation have been identified from five human and rodent genomic sequence comparisons. First, a divergent pattern was observed in the noncoding sequences of the beta-globin and gamma-crystallin gene clusters, and second, a highly conserved pattern was observed in the noncoding regions of the T cell receptor C alpha-C delta, and the alpha- and beta-myosin-heavy-chain genes. A third, mixed pattern has also been found in the immunoglobulin IgH C mu-C delta gene region These three patterns of genomic evolution pose the fascinating possibility that large portions of the genome evolve at different rates.

引用

页码：367 / 371

页数：5

共 25 条

[1]

BERNARDI G, 1993, MOL BIOL EVOL, V10, P186

[2]

BOULIKAS T, 1992, J MOL EVOL, V35, P156, DOI 10.1007/BF00183227

[3]

BRITTEN RJ, 1993, MOL BIOL EVOL, V10, P205

[4] SYNONYMOUS NUCLEOTIDE SUBSTITUTION RATES IN MAMMALIAN GENES - IMPLICATIONS FOR THE MOLECULAR CLOCK AND THE RELATIONSHIP OF MAMMALIAN ORDERS [J].